The Therapeutic Effect of Sulfadiazine and Immune Rabbit Serum in Experimental Murine Pertussis *
نویسندگان
چکیده
Although certain members of the sulfonamide group of drugs have been used in the treatment of the complications of whooping cough,4' 5' 7, 8, 9, 12, 13 but little attention has been given to their effect on the specific organism, Hemophilus pertwssis. Previous work"' has failed to show a favorable influence of sulfanilamide and sulfapyridine on the course of experimental pertussis in the mouse. A recent report by Hornibrook' indicates that sulfadiazine is definitely effective on the course of experimental infection produced by H. pertussis in the rat. Hornibrook's report and our own studies on immune rabbit serums led us to investigate the effect of sulfadiazine alone and in combination with serum in experimental pertussis.
منابع مشابه
Proliferate Resonse to Purified Bordetella pertussis Toxin on Murine Spleen Lymphocytes
A purification procedure of pertussis toxin (PT) from submerged culture of Bordetella pertussis (B.pertussis) strain 134 using adsorption and affinity chromatography was discussed. The yield of the resulting PT was approximately 37.5mg/l of concentrated culture supernatant. The polypeptide pattern of the purified PT was investigated by SDS-PAGE and showed five bands between 11 to 26 KDa using l...
متن کاملSubcutaneous administration of a fusion protein composed of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis induces mucosal and systemic immune responses
Objective(s): After decades of containment, pertussis disease, caused by Bordetella pertussis seems to be re-emerging and still remains a major cause of reported vaccine-preventable deaths worldwide. The current licensed whole-cell vaccines display reactogenicity while acellular vaccines are expensive and do not induce Th1-type immune responses that are required for optimum protection against t...
متن کاملEVALUATION OF SERUM OPSONIC CAPACITY AGAINST BORDETELLA PERTUSSIS BY CHEMILUMINESCENCE
Serum opsonic capacity against B. pertussis was studied by using quantitative chemiluminescence (CL), a method known to have several advantages over conventional methods in evaluating opsonization and phagocytosis. Sera from unvaccinated infants was shown not to contain opsonins against B. pertussis and in unvaccinated infants suffering from whooping cough, no opsonins were detected. In ad...
متن کاملEffect of Pistacia atlantica Mastic Extract on Experimental Wound Healing and Various Biochemical Parameters of Blood Serum in Rabbit Models
Background: The mastic extract of Pistacia species can be considered as a natural herbal source in the pharmaceutical industry. Objective: The purpose of this study was to evaluate the effectiveness of Pistacia atlantica mastic on wound healing, oxidative and blood biochemical parameters. Methods: Topical cream and oral suspension was made of the mastic of P. atlantica, after preparing hydr...
متن کاملComparison of Healing Effect of Aloe Vera Extract and Silver Sulfadiazine in Burn Injuries in Experimental Rat Model
BACKGROUND Wound healing is widely discussed in the medical literature. This study compared the healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. METHODS Sixteen rats were randomly assigned to one of two groups, each group 8 rats. A deep second-degree burn on the lower back and 3rd degree burn on upper back of each rat were created with a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 16 شماره
صفحات -
تاریخ انتشار 1944